People who are under the influence of LSD may experience visual and other sensory distortions, changes to their thought processes, as well as intense emotions such as euphoria. To some extent, the effects of LSD can be unpredictable, but the most common ones include altered and/or enhanced sensory perception and changes in thought patterns.
However, as scientific research into psychedelics continues to grow, it has been shown that LSD can help people have meaningful experiences, giving way to insightful new ideas. Adding to this, its use was demonized by the Nixon administration who declared Timothy Leary “the most dangerous man in America” and formally declared the “War on Drugs”. During the 1960s counterculture movement, LSD became popularised through the likes of Timothy Leary, an ex-Harvard psychologist who publicly encouraged young Americans to “turn on, tune in, drop out.” Rising in popularity amongst America’s youth, LSD quickly gained a reputation as a party drug. Many people are apprehensive about taking LSD because of the cultural baggage surrounding its use. Clinical research has shown that this potent psychedelic substance can be highly effective when treating alcohol and opiate addictions.
In recent decades it has been used both recreationally and for therapeutic purposes. Since then, thousands of studies have been done on the effects of LSD. Ergot was used medicinally by midwives to help ease labor pains as early as the 1500s. While LSD is a synthetic substance and was created in a lab, it is derived from ergot, which is a fungus that grows on rye and other grains. LSD’s psychoactive properties weren’t discovered until 19th April 1943, which later came to be known as Bicycle Day, when Hoffman intentionally ingested the substance to ascertain its effects. LSD was first synthesized in 1938 by the Swiss chemist Albert Hofmann while he was working for Sandoz laboratories researching compounds that would act as respiratory and circulatory stimulants. LSD (Lysergic Acid Diethylamide), often referred to as “acid”, has been around in its current form for decades. When she isn’t working or spending time with her family, you can find her running and enjoying the outdoors or reading any book she can get her hands on. She serves on the board of Pathos Education, a non-profit organization whose mission is to provide books for children in Haiti, and Under the Same Tree, a non-profit organization whose mission is to prevent the effects of poverty by creating sustainable income sources for small business owners. She holds a Bachelor’s Degree in Elementary Education from Southern Illinois University- Edwardsville and completed an Administrative Leadership and Policy Studies Program with principal certification from the University of Colorado- Denver. Amber has experience in social media, digital, print and mass media management, copywriting, internal and external communications, and development and strategic planning for both for-profit and non-profit organizations.Īmber is a former elementary school teacher. 25C-NBOMe was identified with an exact mass accuracy of 0.60 ppm.Amber Kraus is the owner and founder of Rise Marketing Solutions. The analysis of an authentic forensic case sample by DSA-TOFMS using the method development parameters demonstrates its utility in forensic laboratories. For the screening of NBOMe designer drug variables on blotter paper, DSA-TOFMS was successful at reducing analysis time to ⿼15 s per sample, for qualitative identification for the selected analytes of interest. Methanol was found to not be a suitable extraction solvent for DSA analysis of these compounds. DSA without any extraction step in addition to the evaluation of methanol, dichloromethane and hexane extractions were conducted.
Preliminary method development work was performed at the University of Central Florida (Orlando, FL). Samples for method development were prepared at Boston University School of Medicine's Biomedical Forensic Sciences program (Boston, MA) and analyzed at the State of Maine Health and Environmental Testing Laboratory's Forensic Chemistry Section (Augusta, ME). In this study, direct sample analysis (DSA)-time of flight mass spectrometry was employed to leverage rapid and sensitive ambient ionization mass spectrometry without chromatographic separation as verified with an authentic case sample. Of particular interest are the variable phenethylamine chemical structures known as ⿿NBOMes⿿, which pose an emerging threat to public health with incidence steadily growing over the past decade. New psychoactive substances (NPS) have been associated with fatalities and severe injuries in a number of cases in the United States and have led investigators to rethink traditional drug monitoring protocols.
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